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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Product use in unapproved indication: Which Medications Are Safest? (792 Drugs Compared)

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792 medications are used for Product use in unapproved indication, with 4,939 combined adverse event reports. The most reported drugs for Product use in unapproved indication are RIFAXIMIN and ABOBOTULINUMTOXINA.

4,939
Total Reports
792
Drugs Used

All Medications for Product use in unapproved indication Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
RIFAXIMIN XIFAXAN 421 5,009 4,847 36.1%
ABOBOTULINUMTOXINA - 334 109 406 1.9%
HYDROXYCHLOROQUINE HYDROXYCHLOROQUINE SULFATE 212 6,506 16,905 9.8%
PRABOTULINUMTOXINA-XVFS - 152 1 19 0.0%
LOTEPREDNOL ETABONATE Zylet 114 4 45 0.2%
DEXAMETHASONE Dexamethasone Sodium Phosphate 105 22,319 51,311 17.8%
DICLOFENAC Diclofenac Sodium Delayed Release 89 6,378 16,398 7.3%
OBETICHOLIC ACID - 87 529 1,402 7.9%
BRIMONIDINE BRIMONIDINE TARTRATE 79 59 367 0.5%
DUPILUMAB Dupixent 74 1,536 17,008 0.4%
ADAPALENE Differin 65 6 68 0.0%
METFORMIN Metformin Hydrochloride 64 11,550 40,702 12.7%
BUPROPION Bupropion Hydrochloride (XL) 63 8,577 10,246 24.1%
BUDESONIDE BREYNA 60 987 6,421 3.9%
MECASERMIN GUNA-IGF 55 10 97 2.1%
MESALAMINE Mesalamine 54 1,744 6,015 9.0%
PREDNISOLONE Prednisolone Sodium Phosphate 53 13,159 32,883 16.3%
METHOTREXATE Methotrexate 51 21,265 68,793 8.4%
RITUXIMAB Rituxan 51 28,910 54,631 16.2%
CERTOLIZUMAB PEGOL Cimzia 45 5,361 17,641 5.4%

View all 792 drugs →

Most Reported Drugs for Product use in unapproved indication

#1 most reported
#2 most reported
#3 most reported