Restless legs syndrome: Which Medications Are Safest? (208 Drugs Compared)
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208 medications are used for Restless legs syndrome, with 6,314 combined adverse event reports. The most reported drugs for Restless legs syndrome are ROTIGOTINE and PRAMIPEXOLE.
6,314
Total Reports
208
Drugs Used
All Medications for Restless legs syndrome Ranked by Safety Reports
| Drug | Brand | Reports | Deaths (all) | Hosp. (all) | Death Rate |
|---|---|---|---|---|---|
| ROTIGOTINE | Neupro | 1,553 | 1,299 | 1,727 | 16.6% |
| PRAMIPEXOLE | Pramipexole Dihydrochloride | 1,552 | 327 | 2,091 | 5.4% |
| ROPINIROLE | ropinirole hydrochloride | 899 | 310 | 1,192 | 7.3% |
| PREGABALIN | Pregabalin | 623 | 8,959 | 22,920 | 8.8% |
| GABAPENTIN | Gabapentin | 619 | 11,101 | 16,499 | 14.9% |
| CLONAZEPAM | Clonazepam | 298 | 8,488 | 12,506 | 21.5% |
| GABAPENTIN ENACARBIL | Horizant | 239 | 649 | 237 | 35.4% |
| PRAMIPEXOLE\PRAMIPEXOLE | - | 88 | 19 | 132 | 5.7% |
| CARBIDOPA\LEVODOPA | - | 44 | 12,844 | 25,836 | 22.0% |
| OXYCODONE | Oxycodone Hydrochloride | 42 | 55,140 | 21,279 | 28.9% |
| REQUIP | - | 41 | 6 | 37 | 3.8% |
| DULOXETINE | Duloxetine Hydrochloride | 37 | 4,044 | 10,622 | 7.7% |
| MIRAPEX | - | 33 | 3 | 25 | 3.9% |
| TRAMADOL | ConZip | 31 | 14,555 | 19,235 | 19.2% |
| BENSERAZIDE\LEVODOPA | - | 29 | 131 | 1,153 | 6.5% |
| METHADONE | METHADONE HYDROCHLORIDE | 28 | 10,719 | 5,514 | 40.8% |
| BENSERAZIDE | - | 27 | 20 | 69 | 16.0% |
| LYRICA | - | 25 | 142 | 504 | 2.7% |
| NEUPRO | - | 24 | 14 | 42 | 12.6% |
| DICLOFENAC | Diclofenac Sodium Delayed Release | 23 | 6,378 | 16,398 | 7.3% |