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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Serotonin syndrome: Which Medications Are Safest? (59 Drugs Compared)

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59 medications are used for Serotonin syndrome, with 219 combined adverse event reports. The most reported drugs for Serotonin syndrome are CYPROHEPTADINE and LORAZEPAM.

219
Total Reports
59
Drugs Used

All Medications for Serotonin syndrome Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
CYPROHEPTADINE Cyproheptadine Hydrochloride 67 59 290 7.8%
LORAZEPAM Lorazepam 52 6,187 15,431 18.5%
DIAZEPAM Diazepam 24 12,045 13,635 31.6%
CODEINE Codeine-Guaifenesin 21 5,971 3,758 27.2%
SODIUM BICARBONATE QUABIC-100 21 783 1,665 24.5%
AMITRIPTYLINE AMITRIPTYLINE HYDROCHLORIDE 16 4,837 7,290 23.7%
DEXTROSE\DEXTROSE - 16 196 483 19.3%
MIDAZOLAM Midazolam 14 1,808 4,691 16.2%
SERTRALINE Sertraline Hydrochloride 14 6,889 19,327 11.5%
FLUOXETINE Fluoxetine 13 5,534 11,247 17.7%
HALOPERIDOL Haloperidol 10 1,882 7,393 11.8%
DEXTROSE Dextrose 6 682 1,687 16.1%
QUETIAPINE Quetiapine 6 13,610 31,386 18.6%
DIPHENHYDRAMINE Allergy Relief 5 10,508 6,849 40.7%
PROPOFOL Propofol 5 1,970 6,577 12.3%

View all 59 drugs →

Most Reported Drugs for Serotonin syndrome

#1 most reported
#2 most reported
#3 most reported