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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Skin hyperpigmentation: Which Medications Are Safest? (57 Drugs Compared)

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57 medications are used for Skin hyperpigmentation, with 2,490 combined adverse event reports. The most reported drugs for Skin hyperpigmentation are ADAPALENE and AVOBENZONE\OCTISALATE\OCTOCRYLENE.

2,490
Total Reports
57
Drugs Used

All Medications for Skin hyperpigmentation Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
ADAPALENE Differin 2,262 6 68 0.0%
AVOBENZONE\OCTISALATE\OCTOCRYLENE - 1,845 2 32 0.0%
AVOBENZONE\HOMOSALATE\OCTINOXATE\OCTISALATE\OXYBENZONE - 121 0 7 N/A
FLUOCINOLONE ACETONIDE\HYDROQUINONE\TRETINOIN - 103 0 1 N/A
HYDROQUINONE Obagi-C Rx system C-Therapy Night Skin Lightening with Vitamins C and E 28 14 15 5.1%
TRETINOIN Tretinoin 25 576 837 13.9%
DUPILUMAB Dupixent 10 1,536 17,008 0.4%
TACROLIMUS Tacrolimus 5 14,642 36,664 16.1%
TRI-LUMA (FLUOCINOLONE ACETONIDE , HYDROQUINONE , TRETINO - 5 0 0 N/A

View all 57 drugs →

Most Reported Drugs for Skin hyperpigmentation

#1 most reported