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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Sleep disorder therapy: Which Medications Are Safest? (148 Drugs Compared)

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148 medications are used for Sleep disorder therapy, with 1,841 combined adverse event reports. The most reported drugs for Sleep disorder therapy are DIPHENHYDRAMINE\NAPROXEN and MELATONIN.

1,841
Total Reports
148
Drugs Used

All Medications for Sleep disorder therapy Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
DIPHENHYDRAMINE\NAPROXEN - 339 39 48 2.0%
MELATONIN Melatonin 1527 275 812 2,253 19.8%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 250 30,085 50,046 22.0%
IPRATROPIUM Ipratropium bromide 235 860 3,389 11.4%
ACETAMINOPHEN\DIPHENHYDRAMINE - 113 755 723 44.5%
RISPERIDONE Risperidone 110 4,120 18,771 5.2%
DIPHENHYDRAMINE Allergy Relief 88 10,508 6,849 40.7%
SUVOREXANT BELSOMRA 73 219 572 2.3%
CETIRIZINE Cetirizine 55 4,787 8,423 10.0%
IPRATROPIUM\IPRATROPIUM ANHYDROUS - 55 96 147 22.6%
CLONAZEPAM Clonazepam 43 8,488 12,506 21.5%
MIRTAZAPINE Mirtazapine 37 5,410 11,495 18.9%
NAPROXEN Naproxen Sodium 37 5,127 12,849 9.7%
ZOLPIDEM Zolpidem Tartrate 35 3,908 7,033 18.2%
LORAZEPAM Lorazepam 34 6,187 15,431 18.5%
QUETIAPINE Quetiapine 31 13,610 31,386 18.6%
TRAZODONE Trazodone Hydrochloride 31 6,213 7,153 32.4%
ZOPICLONE - 28 2,624 7,438 18.5%
ALPRAZOLAM Alprazolam 18 16,072 15,996 33.2%
IBUPROFEN equate ibuprofen 15 6,705 29,386 7.7%

View all 148 drugs →

Most Reported Drugs for Sleep disorder therapy

#1 most reported
#2 most reported
#3 most reported