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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Substance use: Which Medications Are Safest? (181 Drugs Compared)

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181 medications are used for Substance use, with 818 combined adverse event reports. The most reported drugs for Substance use are KETAMINE and PREGABALIN.

818
Total Reports
181
Drugs Used

All Medications for Substance use Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
KETAMINE KETAMINE HYDROCHLORIDE 94 1,009 3,362 12.6%
PREGABALIN Pregabalin 67 8,959 22,920 8.8%
CANNABIS SATIVA SUBSP. INDICA TOP - 46 3,040 2,907 35.2%
METHADONE METHADONE HYDROCHLORIDE 46 10,719 5,514 40.8%
NITROUS Nitrous Oxide 44 129 440 12.3%
COCAINE NUMBRINO 37 8,171 3,863 57.5%
MORPHINE Morphine Sulfate 37 38,212 17,386 31.7%
BUPRENORPHINE\NALOXONE - 35 1,119 2,872 5.2%
DELTA.8-TETRAHYDROCANNABINOL\HERBALS - 35 14 121 3.8%
CLONAZEPAM Clonazepam 34 8,488 12,506 21.5%
DIAZEPAM Diazepam 28 12,045 13,635 31.6%
DIAMORPHINE - 25 4,735 1,656 52.6%
BUPRENORPHINE Buprenorphine and Naloxone 24 25,813 9,467 31.5%
SILDENAFIL Sildenafil 24 4,979 8,623 14.1%
AMBRISENTAN AMBRISENTAN 23 10,291 32,910 11.9%
HERBALS\MITRAGYNINE - 23 524 267 48.1%
ARIPIPRAZOLE Aripiprazole 21 3,863 20,713 5.8%
FENTANYL FENTANYL 21 42,491 15,153 45.0%
OXYCODONE Oxycodone Hydrochloride 20 55,140 21,279 28.9%
QUETIAPINE Quetiapine 20 13,610 31,386 18.6%

View all 181 drugs →

Most Reported Drugs for Substance use

#1 most reported
#2 most reported