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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Substance use disorder: Which Medications Are Safest? (58 Drugs Compared)

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58 medications are used for Substance use disorder, with 277 combined adverse event reports. The most reported drugs for Substance use disorder are BUPRENORPHINE and BUPRENORPHINE\NALOXONE.

277
Total Reports
58
Drugs Used

All Medications for Substance use disorder Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
BUPRENORPHINE Buprenorphine and Naloxone 64 25,813 9,467 31.5%
BUPRENORPHINE\NALOXONE - 45 1,119 2,872 5.2%
NALTREXONE NALTREXONE HYDROCHLORIDE 44 1,106 2,843 4.3%
METHADONE METHADONE HYDROCHLORIDE 32 10,719 5,514 40.8%
NALOXONE Naloxone Hydrochloride 32 779 1,033 27.2%
DIAMORPHINE - 17 4,735 1,656 52.6%
ARIPIPRAZOLE Aripiprazole 8 3,863 20,713 5.8%
INVESTIGATIONAL PRODUCT - 7 740 4,035 13.8%
VALPROIC ACID Valproic Acid 7 2,667 8,183 13.3%
CANNABIS SATIVA SUBSP. INDICA TOP - 6 3,040 2,907 35.2%
CARIPRAZINE Vraylar 6 194 702 3.0%
COCAINE NUMBRINO 5 8,171 3,863 57.5%
RISPERIDONE Risperidone 5 4,120 18,771 5.2%

View all 58 drugs →

Most Reported Drugs for Substance use disorder

#1 most reported
#2 most reported
#3 most reported