Skip to content
Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Toothache: Which Medications Are Safest? (222 Drugs Compared)

Healthy Teeth & Gums — The Probiotic Way

ProDentim: 3.5 billion good bacteria for a healthier mouth. No chemicals.

See How It Works

222 medications are used for Toothache, with 3,148 combined adverse event reports. The most reported drugs for Toothache are IBUPROFEN and ACETAMINOPHEN.

3,148
Total Reports
222
Drugs Used

All Medications for Toothache Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
IBUPROFEN equate ibuprofen 1,034 6,705 29,386 7.7%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 840 30,085 50,046 22.0%
AMOXICILLIN Amoxicillin and Clavulanate Potassium 235 1,212 11,721 4.0%
NAPROXEN Naproxen Sodium 205 5,127 12,849 9.7%
DICLOFENAC Diclofenac Sodium Delayed Release 132 6,378 16,398 7.3%
TRAMADOL ConZip 125 14,555 19,235 19.2%
ACETAMINOPHEN\CODEINE - 98 3,387 4,926 22.3%
ACETAMINOPHEN\HYDROCODONE - 78 31,727 6,901 29.1%
METRONIDAZOLE metronidazole 64 2,188 7,909 9.7%
ACETAMINOPHEN\ASPIRIN\CAFFEINE - 53 155 438 1.3%
ACETAMINOPHEN\IBUPROFEN - 51 21 59 0.7%
OXYCODONE Oxycodone Hydrochloride 48 55,140 21,279 28.9%
BENZOCAINE ANAL-ESE 47 42 214 7.7%
CLINDAMYCIN XACIATO 44 986 5,320 5.8%
KETOPROFEN Orudis 41 393 2,947 7.1%
DIPHENHYDRAMINE\IBUPROFEN - 36 111 118 2.8%
AMOXICILLIN\CLAVULANIC ACID - 33 885 5,097 8.4%
KETOPROFEN LYSINE - 33 1 177 0.3%
AMOXICILLIN\CLAVULANATE - 32 998 6,376 6.5%
ACETAMINOPHEN\OXYCODONE - 26 31,342 7,703 31.5%

View all 222 drugs →

Most Reported Drugs for Toothache

#1 most reported
#2 most reported
#3 most reported