Does ALLOPURINOL Cause Nikolsky's sign? 22 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 22 reports of Nikolsky's sign have been filed in association with ALLOPURINOL (Allopurinol). This represents 0.1% of all adverse event reports for ALLOPURINOL.
22
Reports of Nikolsky's sign with ALLOPURINOL
0.1%
of all ALLOPURINOL reports
21
Deaths
7
Hospitalizations
How Dangerous Is Nikolsky's sign From ALLOPURINOL?
Of the 22 reports, 21 (95.5%) resulted in death, 7 (31.8%) required hospitalization, and 5 (22.7%) were considered life-threatening.
Is Nikolsky's sign Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ALLOPURINOL. However, 22 reports have been filed with the FAERS database.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Nikolsky's sign?
LAMOTRIGINE (46)
PANTOPRAZOLE (39)
FUROSEMIDE (33)
ATORVASTATIN (29)
DIGITOXIN (25)
IBUPROFEN (24)
CARBAMAZEPINE (23)
CHOLECALCIFEROL (23)
ACETAMINOPHEN (21)
SULFAMETHOXAZOLE\TRIMETHOPRIM (19)
Which ALLOPURINOL Alternatives Have Lower Nikolsky's sign Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN