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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

CANAGLIFLOZIN\METFORMIN: 1,544 Adverse Event Reports & Safety Profile

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1,544
Total FAERS Reports
27 (1.7%)
Deaths Reported
615
Hospitalizations
1,544
As Primary/Secondary Suspect
44
Life-Threatening
81
Disabilities

Active Ingredient: CANAGLIFLOZIN\METFORMIN HYDROCHLORIDE ·

First Report: 2000 · Latest Report: 20250614

What Are the Most Common CANAGLIFLOZIN\METFORMIN Side Effects?

#1 Most Reported
Osteomyelitis
197 reports (12.8%)
#2 Most Reported
Toe amputation
196 reports (12.7%)
#3 Most Reported
Diabetic ketoacidosis
185 reports (12.0%)

All CANAGLIFLOZIN\METFORMIN Side Effects by Frequency

Side Effect Reports % of Total Deaths Hosp.
Osteomyelitis 197 12.8% 2 167
Toe amputation 196 12.7% 2 145
Diabetic ketoacidosis 185 12.0% 1 173
Acute kidney injury 105 6.8% 2 98
Cellulitis 92 6.0% 2 83
Diabetic foot infection 85 5.5% 0 79
Gangrene 82 5.3% 0 76
Blood glucose increased 69 4.5% 0 6
Off label use 67 4.3% 0 13
Diabetic foot 65 4.2% 0 57
Leg amputation 62 4.0% 1 58
Foot amputation 59 3.8% 0 55
Weight decreased 58 3.8% 0 4
Nausea 57 3.7% 0 17
Inappropriate schedule of drug administration 56 3.6% 0 3
Fungal infection 53 3.4% 0 3
Diarrhoea 51 3.3% 0 6
Skin ulcer 51 3.3% 1 39
Drug prescribing error 43 2.8% 0 2
Sepsis 42 2.7% 0 42

Who Reports CANAGLIFLOZIN\METFORMIN Side Effects? Age & Gender Data

Gender: 49.6% female, 50.4% male. Average age: 57.7 years. Most reports from: US. View detailed demographics →

Is CANAGLIFLOZIN\METFORMIN Getting Safer? Reports by Year

YearReportsDeathsHosp.
2000 1 0 1
2010 1 0 0
2011 2 0 2
2012 2 0 0
2013 5 0 3
2014 51 1 26
2015 288 1 156
2016 260 3 144
2017 171 1 111
2018 79 6 52
2019 25 2 11
2020 6 0 2
2021 10 1 4
2022 6 0 4
2023 5 0 1
2024 10 0 9
2025 3 0 2

View full timeline →

What Is CANAGLIFLOZIN\METFORMIN Used For?

IndicationReports
Product used for unknown indication 711
Type 2 diabetes mellitus 598
Diabetes mellitus 184
Diabetes mellitus inadequate control 10
Diabetes mellitus management 9
Type 1 diabetes mellitus 8
Blood glucose increased 6

CANAGLIFLOZIN\METFORMIN vs Alternatives: Which Is Safer?

CANAGLIFLOZIN\METFORMIN vs CANAKINUMAB CANAGLIFLOZIN\METFORMIN vs CANDESARTAN CANAGLIFLOZIN\METFORMIN vs CANDESARTAN CILEXETIL CANAGLIFLOZIN\METFORMIN vs CANDESARTAN CILEXETIL\HYDROCHLOROTHIAZIDE CANAGLIFLOZIN\METFORMIN vs CANGRELOR CANAGLIFLOZIN\METFORMIN vs CANIS LUPUS FAMILIARIS SKIN CANAGLIFLOZIN\METFORMIN vs CANNABIDIOL CANAGLIFLOZIN\METFORMIN vs CANNABIDIOL\HERBALS CANAGLIFLOZIN\METFORMIN vs CANNABIS SATIVA FLOWERING TOP CANAGLIFLOZIN\METFORMIN vs CANNABIS SATIVA SUBSP. INDICA TOP

Official FDA Label for CANAGLIFLOZIN\METFORMIN

Official prescribing information from the FDA-approved drug label.