COBIMETINIB for Soft tissue sarcoma: Side Effects & Safety Data
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There are 22 adverse event reports in the FDA FAERS database where COBIMETINIB was used for Soft tissue sarcoma.
Most Reported Side Effects for COBIMETINIB
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Diarrhoea | 412 | 10.1% | 39 | 214 |
| Off label use | 411 | 10.1% | 40 | 65 |
| Rash | 369 | 9.1% | 11 | 166 |
| Pyrexia | 332 | 8.2% | 19 | 228 |
| Death | 231 | 5.7% | 230 | 23 |
| Nausea | 206 | 5.1% | 17 | 105 |
| Fatigue | 198 | 4.9% | 15 | 93 |
| No adverse event | 178 | 4.4% | 0 | 1 |
| Vomiting | 168 | 4.1% | 20 | 108 |
| Acute kidney injury | 133 | 3.3% | 18 | 114 |
| Photosensitivity reaction | 124 | 3.1% | 10 | 44 |
| Asthenia | 119 | 2.9% | 13 | 68 |
| Rash maculo-papular | 118 | 2.9% | 7 | 73 |
| Blood creatine phosphokinase increased | 114 | 2.8% | 5 | 58 |
| Drug reaction with eosinophilia and systemic symptoms | 113 | 2.8% | 6 | 72 |
Other Indications for COBIMETINIB
Malignant melanoma (1,324)
Metastatic malignant melanoma (898)
Product used for unknown indication (402)
Histiocytosis (98)
Erdheim-chester disease (90)
Plasma cell myeloma (76)
Neoplasm malignant (70)
Neoplasm (68)
Langerhans' cell histiocytosis (56)
Cholangiocarcinoma (53)
Other Drugs Used for Soft tissue sarcoma
PAZOPANIB (1,400)
DOXORUBICIN (302)
TAZEMETOSTAT HYDROBROMIDE (298)
IFOSFAMIDE (237)
CABOZANTINIB S-MALATE (192)
TRABECTEDIN (183)
NIVOLUMAB (156)
OLARATUMAB (156)
IMATINIB (124)
SUNITINIB MALATE (123)