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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

ESTRADIOL: Side Effect Reports by Year

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Year-by-year breakdown of FAERS adverse event reports for ESTRADIOL. Total: 31,135 reports.

Year Reports Deaths Hospitalizations Death Rate
2000 14 0 4 N/A
2001 12 0 1 N/A
2002 14 1 4 7.1%
2003 13 0 5 N/A
2004 14 1 9 7.1%
2005 15 1 4 6.7%
2006 17 0 1 N/A
2007 36 0 21 N/A
2008 29 0 13 N/A
2009 18 0 4 N/A
2010 49 1 25 2.0%
2011 46 1 6 2.2%
2012 71 2 15 2.8%
2013 159 0 35 N/A
2014 788 3 58 0.4%
2015 1,027 3 64 0.3%
2016 1,184 1 76 0.1%
2017 1,160 12 112 1.0%
2018 1,395 9 107 0.6%
2019 1,974 14 112 0.7%
2020 1,176 12 61 1.0%
2021 966 13 69 1.3%
2022 757 3 52 0.4%
2023 742 5 56 0.7%
2024 743 17 55 2.3%
2025 641 0 33 N/A
Total 31,135 267 1,953 0.9%

FDA approval date: Approved Prior to Jan 1, 1982.

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