Does METFORMIN Cause Nephrolithiasis? 351 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 351 reports of Nephrolithiasis have been filed in association with METFORMIN (Metformin Hydrochloride). This represents 0.4% of all adverse event reports for METFORMIN.
351
Reports of Nephrolithiasis with METFORMIN
0.4%
of all METFORMIN reports
18
Deaths
249
Hospitalizations
How Dangerous Is Nephrolithiasis From METFORMIN?
Of the 351 reports, 18 (5.1%) resulted in death, 249 (70.9%) required hospitalization, and 46 (13.1%) were considered life-threatening.
Is Nephrolithiasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METFORMIN. However, 351 reports have been filed with the FAERS database.
What Other Side Effects Does METFORMIN Cause?
Lactic acidosis (16,316)
Acute kidney injury (11,361)
Diarrhoea (7,679)
Toxicity to various agents (5,669)
Metabolic acidosis (5,236)
Hypoglycaemia (5,047)
Drug ineffective (4,991)
Nausea (4,915)
Vomiting (4,624)
Blood glucose increased (4,038)
What Other Drugs Cause Nephrolithiasis?
ADALIMUMAB (2,416)
ETANERCEPT (1,292)
INFLIXIMAB (981)
METHOTREXATE (979)
ABATACEPT (788)
TOPIRAMATE (768)
CERTOLIZUMAB PEGOL (735)
RITUXIMAB (709)
TOFACITINIB (699)
SODIUM OXYBATE (698)
Which METFORMIN Alternatives Have Lower Nephrolithiasis Risk?
METFORMIN vs METFORMIN\PIOGLITAZONE
METFORMIN vs METFORMIN\ROSIGLITAZONE
METFORMIN vs METFORMIN\SAXAGLIPTIN
METFORMIN vs METFORMIN\SITAGLIPTIN
METFORMIN vs METFORMIN\VILDAGLIPTIN