Does SPIRONOLACTONE Cause Hypospadias? 11 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 11 reports of Hypospadias have been filed in association with SPIRONOLACTONE (spironolactone). This represents 0.1% of all adverse event reports for SPIRONOLACTONE.
11
Reports of Hypospadias with SPIRONOLACTONE
0.1%
of all SPIRONOLACTONE reports
6
Deaths
10
Hospitalizations
How Dangerous Is Hypospadias From SPIRONOLACTONE?
Of the 11 reports, 6 (54.5%) resulted in death, 10 (90.9%) required hospitalization.
Is Hypospadias Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for SPIRONOLACTONE. However, 11 reports have been filed with the FAERS database.
What Other Side Effects Does SPIRONOLACTONE Cause?
Acute kidney injury (3,273)
Hyperkalaemia (2,518)
Hypotension (1,583)
Dyspnoea (1,468)
Drug ineffective (1,379)
Hyponatraemia (1,166)
Dizziness (991)
Fatigue (990)
Fall (947)
Off label use (899)
What Other Drugs Cause Hypospadias?
LAMOTRIGINE (131)
VALPROATE (92)
TOPIRAMATE (83)
VALPROIC ACID (79)
LEVETIRACETAM (75)
QUETIAPINE (64)
METHYLDOPA (62)
CITALOPRAM HYDROBROMIDE (60)
CARBAMAZEPINE (57)
FLUOXETINE (54)
Which SPIRONOLACTONE Alternatives Have Lower Hypospadias Risk?
SPIRONOLACTONE vs SPRYCEL
SPIRONOLACTONE vs STALEVO
SPIRONOLACTONE vs STANNOUS FLUORIDE
SPIRONOLACTONE vs STANOZOLOL
SPIRONOLACTONE vs STAVUDINE