Hypospadias: Which Medications Cause It? (1,274 Reports Across 123 Drugs)
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Hypospadias has been reported as an adverse event with 123 different drugs in the FDA's FAERS database, with 1,274 total reports. 29 of these reports resulted in death.The drugs most commonly associated with Hypospadias are LAMOTRIGINE, VALPROATE, and TOPIRAMATE.
1,274
Total Reports
123
Drugs Involved
29
Deaths
120
Hospitalizations
8.5 yrs
Average Patient Age
1.3% / 98.7%
Female / Male
Which Drugs Cause Hypospadias Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| LAMOTRIGINE | 131 | 0.3% | 1 | 5 | 2 |
| VALPROATE | 92 | 0.6% | 2 | 20 | 0 |
| TOPIRAMATE | 83 | 0.3% | 0 | 3 | 0 |
| VALPROIC ACID | 79 | 0.4% | 0 | 5 | 1 |
| LEVETIRACETAM | 75 | 0.1% | 2 | 2 | 3 |
| QUETIAPINE | 64 | 0.1% | 2 | 1 | 0 |
| METHYLDOPA | 62 | 2.4% | 2 | 1 | 0 |
| CITALOPRAM HYDROBROMIDE | 60 | 0.2% | 0 | 0 | 2 |
| CARBAMAZEPINE | 57 | 0.2% | 0 | 1 | 0 |
| FLUOXETINE | 54 | 0.2% | 0 | 10 | 2 |
| SERTRALINE | 50 | 0.1% | 1 | 7 | 1 |
| ARIPIPRAZOLE | 47 | 0.1% | 0 | 6 | 0 |
| METOPROLOL | 46 | 0.1% | 0 | 1 | 1 |
| VENLAFAXINE | 42 | 0.1% | 0 | 0 | 0 |
| ONDANSETRON | 34 | 0.2% | 2 | 4 | 0 |
| ZIDOVUDINE | 31 | 0.5% | 0 | 2 | 0 |
| ESCITALOPRAM OXALATE | 29 | 0.1% | 2 | 1 | 0 |
| CLOBAZAM | 27 | 0.3% | 0 | 0 | 0 |
| LAMIVUDINE | 25 | 0.2% | 0 | 1 | 0 |
| MIRTAZAPINE | 25 | 0.1% | 0 | 1 | 0 |