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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Breakthrough pain: Which Medications Are Safest? (100 Drugs Compared)

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100 medications are used for Breakthrough pain, with 2,774 combined adverse event reports. The most reported drugs for Breakthrough pain are FENTANYL and OXYCODONE.

2,774
Total Reports
100
Drugs Used

All Medications for Breakthrough pain Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
FENTANYL FENTANYL 1,343 42,491 15,153 45.0%
OXYCODONE Oxycodone Hydrochloride 520 55,140 21,279 28.9%
HYDROMORPHONE Hydromorphone Hydrochloride 223 28,491 10,395 34.1%
MORPHINE Morphine Sulfate 219 38,212 17,386 31.7%
TAPENTADOL Nucynta 123 20,205 3,304 69.2%
ACETAMINOPHEN\HYDROCODONE - 111 31,727 6,901 29.1%
ACETAMINOPHEN\OXYCODONE - 110 31,342 7,703 31.5%
ACETAMINOPHEN\OXYCODONE\OXYCODONE TEREPHTHALATE - 54 1,069 809 9.1%
HYDROCODONE Hydrocodone Bitartrate 47 24,200 3,569 50.6%
TRAMADOL ConZip 38 14,555 19,235 19.2%
PREGABALIN Pregabalin 31 8,959 22,920 8.8%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 27 30,085 50,046 22.0%
BUPRENORPHINE Buprenorphine and Naloxone 26 25,813 9,467 31.5%
FENTANYL\FENTANYL - 21 1,564 1,000 41.9%
ACTIQ - 19 35 20 32.4%
METHADONE METHADONE HYDROCHLORIDE 19 10,719 5,514 40.8%
OXYMORPHONE Oxymorphone Hydrochloride 17 22,403 2,692 58.8%
IBUPROFEN equate ibuprofen 9 6,705 29,386 7.7%
BUPIVACAINE Bupivacaine Hydrochloride 7 466 2,367 4.1%
FENTORA - 7 74 15 58.3%

View all 100 drugs →

Most Reported Drugs for Breakthrough pain

#1 most reported
#2 most reported
#3 most reported