Depression: Which Medications Are Safest? (1,017 Drugs Compared)
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1,017 medications are used for Depression, with 114,648 combined adverse event reports. The most reported drugs for Depression are SERTRALINE and VENLAFAXINE.
114,648
Total Reports
1,017
Drugs Used
All Medications for Depression Ranked by Safety Reports
| Drug | Brand | Reports | Deaths (all) | Hosp. (all) | Death Rate |
|---|---|---|---|---|---|
| SERTRALINE | Sertraline Hydrochloride | 14,497 | 6,889 | 19,327 | 11.5% |
| VENLAFAXINE | Venlafaxine Hydrochloride | 11,868 | 7,521 | 15,749 | 15.7% |
| DULOXETINE | Duloxetine Hydrochloride | 11,681 | 4,044 | 10,622 | 7.7% |
| ESKETAMINE | Spravato | 10,058 | 637 | 2,919 | 4.2% |
| ESCITALOPRAM OXALATE | Escitalopram | 7,373 | 3,531 | 11,942 | 11.6% |
| FLUOXETINE | Fluoxetine | 7,035 | 5,534 | 11,247 | 17.7% |
| BUPROPION | Bupropion Hydrochloride (XL) | 6,165 | 8,577 | 10,246 | 24.1% |
| MIRTAZAPINE | Mirtazapine | 6,021 | 5,410 | 11,495 | 18.9% |
| CITALOPRAM HYDROBROMIDE | Citalopram Hydrobromide | 5,450 | 6,745 | 9,074 | 24.9% |
| PAROXETINE | Paroxetine | 5,386 | 2,854 | 8,171 | 13.3% |
| VORTIOXETINE HYDROBROMIDE | Trintellix | 4,881 | 400 | 1,741 | 2.9% |
| ARIPIPRAZOLE | Aripiprazole | 4,543 | 3,863 | 20,713 | 5.8% |
| QUETIAPINE | Quetiapine | 4,370 | 13,610 | 31,386 | 18.6% |
| RISPERIDONE | Risperidone | 3,356 | 4,120 | 18,771 | 5.2% |
| DESVENLAFAXINE | Desvenlafaxine Succinate | 2,714 | 447 | 1,093 | 5.0% |
| BREXPIPRAZOLE | Rexulti | 1,896 | 673 | 1,269 | 5.1% |
| OLANZAPINE | Olanzapine | 1,690 | 5,535 | 21,934 | 10.8% |
| LAMOTRIGINE | Lamotrigine ER | 1,652 | 6,604 | 17,639 | 13.7% |
| TRAZODONE | Trazodone Hydrochloride | 1,468 | 6,213 | 7,153 | 32.4% |
| AMITRIPTYLINE | AMITRIPTYLINE HYDROCHLORIDE | 1,410 | 4,837 | 7,290 | 23.7% |