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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Epilepsy: Which Medications Are Safest? (540 Drugs Compared)

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540 medications are used for Epilepsy, with 58,474 combined adverse event reports. The most reported drugs for Epilepsy are LEVETIRACETAM and LAMOTRIGINE.

58,474
Total Reports
540
Drugs Used

All Medications for Epilepsy Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
LEVETIRACETAM Levetiracetam 17,599 4,322 19,165 6.9%
LAMOTRIGINE Lamotrigine ER 8,886 6,604 17,639 13.7%
LACOSAMIDE Lacosamide 5,941 1,987 6,845 9.4%
CANNABIDIOL Epidiolex 5,555 1,563 5,149 8.6%
CARBAMAZEPINE Carbamazepine 4,329 2,156 9,608 8.8%
VALPROATE Valproate Sodium 3,697 1,000 6,625 6.3%
VALPROIC ACID Valproic Acid 3,229 2,667 8,183 13.3%
VIGABATRIN Vigabatrin 2,896 1,091 3,607 9.0%
CLOBAZAM Clobazam 2,840 725 3,312 6.8%
TOPIRAMATE Topiramate 2,828 3,527 7,098 12.3%
PHENYTOIN PHENYTOIN SODIUM 2,376 1,449 5,241 10.0%
CENOBAMATE Xcopri 2,230 125 1,012 2.2%
OXCARBAZEPINE OXCARBAZEPINE 2,088 864 3,159 8.0%
BRIVARACETAM Brivaracetam 1,853 317 1,536 5.2%
PERAMPANEL Fycompa 1,402 249 1,760 5.6%
CLONAZEPAM Clonazepam 1,164 8,488 12,506 21.5%
ZONISAMIDE Zonisamide 1,145 299 1,424 6.3%
PHENOBARBITAL Phenobarbital Sodium 1,116 945 2,668 14.6%
DIVALPROEX Divalproex Sodium 859 478 4,169 4.2%
ESLICARBAZEPINE Eslicarbazepine Acetate 805 97 750 3.1%

View all 540 drugs →

Most Reported Drugs for Epilepsy

#1 most reported
#2 most reported
#3 most reported