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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Local anaesthesia: Which Medications Are Safest? (135 Drugs Compared)

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135 medications are used for Local anaesthesia, with 4,218 combined adverse event reports. The most reported drugs for Local anaesthesia are LIDOCAINE and EPINEPHRINE\LIDOCAINE.

4,218
Total Reports
135
Drugs Used

All Medications for Local anaesthesia Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
LIDOCAINE Burn Relief 1,741 1,738 5,570 7.6%
EPINEPHRINE\LIDOCAINE - 856 36 311 1.5%
ARTICAINE\EPINEPHRINE - 602 16 164 1.0%
BUPIVACAINE Bupivacaine Hydrochloride 374 466 2,367 4.1%
ROPIVACAINE Ropivacaine Hydrochloride 281 150 921 5.1%
EPINEPHRINE EPINEPHRINE 217 1,469 4,388 9.7%
MEPIVACAINE Mepivacaine 141 19 183 2.7%
LIDOCAINE\PRILOCAINE - 87 8 156 1.6%
PROCAINE TKTX NUMB 59 16 36 4.5%
MEPIVACAINE\MEPIVACAINE - 55 5 42 3.2%
BUPIVACAINE\EPINEPHRINE - 48 5 14 2.9%
PRILOCAINE Citanest Plain 42 2 75 0.8%
BENZOCAINE ANAL-ESE 40 42 214 7.7%
SODIUM BICARBONATE QUABIC-100 31 783 1,665 24.5%
ARTICAINE Articaine Hydrochloride and Epinephrine 29 7 49 7.4%
LEVOBUPIVACAINE - 27 12 150 3.0%
PROPARACAINE Proparacaine hydrochloride 27 0 37 N/A
HYALURONIDASE Phesgo 24 470 775 42.5%
FENTANYL FENTANYL 22 42,491 15,153 45.0%
TETRACAINE Tetracaine Hydrochloride 18 5 19 2.5%

View all 135 drugs →

Most Reported Drugs for Local anaesthesia

#1 most reported
#2 most reported
#3 most reported