Major depression: Which Medications Are Safest? (367 Drugs Compared)
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367 medications are used for Major depression, with 22,443 combined adverse event reports. The most reported drugs for Major depression are BREXPIPRAZOLE and ARIPIPRAZOLE.
22,443
Total Reports
367
Drugs Used
All Medications for Major depression Ranked by Safety Reports
| Drug | Brand | Reports | Deaths (all) | Hosp. (all) | Death Rate |
|---|---|---|---|---|---|
| BREXPIPRAZOLE | Rexulti | 3,876 | 673 | 1,269 | 5.1% |
| ARIPIPRAZOLE | Aripiprazole | 2,946 | 3,863 | 20,713 | 5.8% |
| VORTIOXETINE HYDROBROMIDE | Trintellix | 2,506 | 400 | 1,741 | 2.9% |
| DULOXETINE | Duloxetine Hydrochloride | 1,514 | 4,044 | 10,622 | 7.7% |
| VENLAFAXINE | Venlafaxine Hydrochloride | 1,380 | 7,521 | 15,749 | 15.7% |
| ESKETAMINE | Spravato | 1,278 | 637 | 2,919 | 4.2% |
| SERTRALINE | Sertraline Hydrochloride | 1,231 | 6,889 | 19,327 | 11.5% |
| BUPROPION | Bupropion Hydrochloride (XL) | 988 | 8,577 | 10,246 | 24.1% |
| QUETIAPINE | Quetiapine | 949 | 13,610 | 31,386 | 18.6% |
| ESCITALOPRAM OXALATE | Escitalopram | 897 | 3,531 | 11,942 | 11.6% |
| FLUOXETINE | Fluoxetine | 838 | 5,534 | 11,247 | 17.7% |
| MIRTAZAPINE | Mirtazapine | 736 | 5,410 | 11,495 | 18.9% |
| BUPROPION\DEXTROMETHORPHAN HYDROBROMIDE | - | 687 | 16 | 87 | 0.7% |
| RISPERIDONE | Risperidone | 656 | 4,120 | 18,771 | 5.2% |
| OLANZAPINE | Olanzapine | 636 | 5,535 | 21,934 | 10.8% |
| CARIPRAZINE | Vraylar | 551 | 194 | 702 | 3.0% |
| DESVENLAFAXINE | Desvenlafaxine Succinate | 485 | 447 | 1,093 | 5.0% |
| PAROXETINE | Paroxetine | 392 | 2,854 | 8,171 | 13.3% |
| CITALOPRAM HYDROBROMIDE | Citalopram Hydrobromide | 319 | 6,745 | 9,074 | 24.9% |
| VILAZODONE | Vilazodone Hydrochloride | 319 | 181 | 249 | 5.5% |
Most Reported Drugs for Major depression
#1 most reported
#2 most reported
#3 most reported