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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Osteoarthritis: Which Medications Are Safest? (523 Drugs Compared)

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523 medications are used for Osteoarthritis, with 13,853 combined adverse event reports. The most reported drugs for Osteoarthritis are DICLOFENAC and CELECOXIB.

13,853
Total Reports
523
Drugs Used

All Medications for Osteoarthritis Ranked by Safety Reports

Drug Brand Reports Deaths (all) Hosp. (all) Death Rate
DICLOFENAC Diclofenac Sodium Delayed Release 1,696 6,378 16,398 7.3%
CELECOXIB Celecoxib 1,287 4,470 9,081 14.1%
ETANERCEPT ENBREL 1,048 10,338 36,932 2.9%
IBUPROFEN equate ibuprofen 803 6,705 29,386 7.7%
DENOSUMAB Bilprevda 728 19,354 17,749 13.0%
TOFACITINIB XELJANZ XR 694 7,847 21,976 5.0%
ADALIMUMAB YUSIMRY 686 21,807 108,264 4.4%
NAPROXEN Naproxen Sodium 636 5,127 12,849 9.7%
PREGABALIN Pregabalin 450 8,959 22,920 8.8%
TRIAMCINOLONE ACETONIDE Triamcinolone Acetonide 423 1,874 3,276 11.2%
ACETAMINOPHEN Hydrocodone Bitartrate and Acetaminophen 330 30,085 50,046 22.0%
MELOXICAM Meloxicam 280 1,042 2,502 12.0%
DULOXETINE Duloxetine Hydrochloride 239 4,044 10,622 7.7%
ABATACEPT ORENCIA 226 7,681 21,254 6.6%
TRAMADOL ConZip 212 14,555 19,235 19.2%
TOCILIZUMAB Tocilizumab-anoh 173 9,543 24,039 9.7%
METHOTREXATE Methotrexate 166 21,265 68,793 8.4%
TERIPARATIDE Bonsity 162 1,519 5,115 2.2%
APREMILAST Otezla 160 4,704 9,544 3.4%
LIDOCAINE Burn Relief 145 1,738 5,570 7.6%

View all 523 drugs →

Most Reported Drugs for Osteoarthritis

#1 most reported
#2 most reported
#3 most reported