METHOTREXATE for Osteoarthritis: Side Effects & Safety Data

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There are 166 adverse event reports in the FDA FAERS database where METHOTREXATE was used for Osteoarthritis.

Most Reported Side Effects for METHOTREXATE

Side Effect	Reports	%	Deaths	Hosp.
Drug ineffective	70,142	27.6%	2,652	9,752
Rheumatoid arthritis	29,254	11.5%	2,111	6,669
Off label use	24,020	9.5%	3,417	7,881
Pain	23,773	9.4%	1,981	5,911
Drug intolerance	22,555	8.9%	1,490	4,290
Arthralgia	21,831	8.6%	1,776	5,744
Fatigue	19,885	7.8%	2,005	5,458
Nausea	18,715	7.4%	1,537	5,866
Joint swelling	17,657	7.0%	1,963	4,442
Drug hypersensitivity	16,677	6.6%	1,413	3,985
Rash	15,519	6.1%	2,143	4,878
Condition aggravated	14,938	5.9%	1,927	4,851
Treatment failure	14,672	5.8%	1,172	2,598
Alopecia	14,360	5.7%	1,673	3,214
Abdominal discomfort	13,237	5.2%	1,784	3,600