METHOTREXATE for Crohn's disease: Side Effects & Safety Data
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There are 2,432 adverse event reports in the FDA FAERS database where METHOTREXATE was used for Crohn's disease.
Most Reported Side Effects for METHOTREXATE
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Drug ineffective | 70,142 | 27.6% | 2,652 | 9,752 |
| Rheumatoid arthritis | 29,254 | 11.5% | 2,111 | 6,669 |
| Off label use | 24,020 | 9.5% | 3,417 | 7,881 |
| Pain | 23,773 | 9.4% | 1,981 | 5,911 |
| Drug intolerance | 22,555 | 8.9% | 1,490 | 4,290 |
| Arthralgia | 21,831 | 8.6% | 1,776 | 5,744 |
| Fatigue | 19,885 | 7.8% | 2,005 | 5,458 |
| Nausea | 18,715 | 7.4% | 1,537 | 5,866 |
| Joint swelling | 17,657 | 7.0% | 1,963 | 4,442 |
| Drug hypersensitivity | 16,677 | 6.6% | 1,413 | 3,985 |
| Rash | 15,519 | 6.1% | 2,143 | 4,878 |
| Condition aggravated | 14,938 | 5.9% | 1,927 | 4,851 |
| Treatment failure | 14,672 | 5.8% | 1,172 | 2,598 |
| Alopecia | 14,360 | 5.7% | 1,673 | 3,214 |
| Abdominal discomfort | 13,237 | 5.2% | 1,784 | 3,600 |
Other Indications for METHOTREXATE
Rheumatoid arthritis (84,654)
Product used for unknown indication (56,611)
Acute lymphocytic leukaemia (11,187)
Psoriatic arthropathy (6,997)
Psoriasis (6,628)
Prophylaxis against graft versus host disease (5,226)
Diffuse large b-cell lymphoma (2,761)
Juvenile idiopathic arthritis (2,220)
Central nervous system lymphoma (2,075)
Systemic lupus erythematosus (1,440)
Other Drugs Used for Crohn's disease
ADALIMUMAB (99,540)
INFLIXIMAB (40,796)
VEDOLIZUMAB (28,718)
USTEKINUMAB (22,537)
RISANKIZUMAB-RZAA (12,561)
INFLIXIMAB-DYYB (10,657)
HUMIRA (10,174)
CERTOLIZUMAB PEGOL (8,758)
UPADACITINIB (4,390)
MESALAMINE (2,930)