Does CODEINE Cause Serotonin syndrome? 103 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 103 reports of Serotonin syndrome have been filed in association with CODEINE (Codeine-Guaifenesin). This represents 0.5% of all adverse event reports for CODEINE.
103
Reports of Serotonin syndrome with CODEINE
0.5%
of all CODEINE reports
32
Deaths
53
Hospitalizations
How Dangerous Is Serotonin syndrome From CODEINE?
Of the 103 reports, 32 (31.1%) resulted in death, 53 (51.5%) required hospitalization, and 39 (37.9%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
Yes, Serotonin syndrome is listed as a known adverse reaction in the official FDA drug label for CODEINE.
What Other Side Effects Does CODEINE Cause?
Drug hypersensitivity (7,479)
Toxicity to various agents (2,951)
Drug ineffective (2,632)
Drug abuse (2,122)
Pain (2,024)
Rash (1,931)
Nausea (1,907)
Rheumatoid arthritis (1,861)
Headache (1,701)
Off label use (1,662)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which CODEINE Alternatives Have Lower Serotonin syndrome Risk?
CODEINE vs CODEINE\GUAIFENESIN
CODEINE vs CODEINE\IBUPROFEN
CODEINE vs CODEINE\PROMETHAZINE
CODEINE vs COLCHICINE
CODEINE vs COLCHICINE\DICYCLOMINE