Serotonin syndrome: Which Medications Cause It? (13,445 Reports Across 461 Drugs)
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Serotonin syndrome has been reported as an adverse event with 461 different drugs in the FDA's FAERS database, with 13,445 total reports. 841 of these reports resulted in death.The drugs most commonly associated with Serotonin syndrome are VENLAFAXINE, SERTRALINE, and FLUOXETINE.
13,445
Total Reports
461
Drugs Involved
841
Deaths
8,028
Hospitalizations
46.2 yrs
Average Patient Age
58.2% / 41.8%
Female / Male
Which Drugs Cause Serotonin syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| VENLAFAXINE | 1,632 | 3.4% | 125 | 985 | 436 |
| SERTRALINE | 1,563 | 2.6% | 140 | 1,000 | 368 |
| FLUOXETINE | 1,457 | 4.7% | 81 | 817 | 360 |
| DULOXETINE | 1,352 | 2.6% | 83 | 662 | 180 |
| TRAMADOL | 1,229 | 1.6% | 61 | 668 | 277 |
| BUPROPION | 1,058 | 3.0% | 24 | 799 | 199 |
| ESCITALOPRAM OXALATE | 1,051 | 3.5% | 46 | 589 | 258 |
| QUETIAPINE | 947 | 1.3% | 83 | 697 | 247 |
| TRAZODONE | 831 | 4.3% | 39 | 593 | 205 |
| FENTANYL | 778 | 0.8% | 41 | 503 | 238 |
| PAROXETINE | 742 | 3.5% | 45 | 528 | 151 |
| MIRTAZAPINE | 717 | 2.5% | 47 | 472 | 185 |
| ONDANSETRON | 686 | 3.0% | 5 | 499 | 141 |
| CITALOPRAM HYDROBROMIDE | 685 | 2.5% | 69 | 433 | 142 |
| AMITRIPTYLINE | 579 | 2.8% | 27 | 377 | 166 |
| ACETAMINOPHEN | 525 | 0.4% | 59 | 281 | 132 |
| LAMOTRIGINE | 506 | 1.1% | 24 | 393 | 122 |
| LINEZOLID | 498 | 2.8% | 16 | 225 | 88 |
| ARIPIPRAZOLE | 464 | 0.7% | 19 | 350 | 114 |
| OLANZAPINE | 441 | 0.9% | 51 | 328 | 104 |