Does DIPHENHYDRAMINE Cause Serotonin syndrome? 116 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 116 reports of Serotonin syndrome have been filed in association with DIPHENHYDRAMINE (Allergy Relief). This represents 0.5% of all adverse event reports for DIPHENHYDRAMINE.
116
Reports of Serotonin syndrome with DIPHENHYDRAMINE
0.5%
of all DIPHENHYDRAMINE reports
15
Deaths
76
Hospitalizations
How Dangerous Is Serotonin syndrome From DIPHENHYDRAMINE?
Of the 116 reports, 15 (12.9%) resulted in death, 76 (65.5%) required hospitalization, and 16 (13.8%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for DIPHENHYDRAMINE. However, 116 reports have been filed with the FAERS database.
What Other Side Effects Does DIPHENHYDRAMINE Cause?
Toxicity to various agents (4,596)
Drug ineffective (3,511)
Completed suicide (3,081)
Off label use (2,639)
Fatigue (2,605)
Drug abuse (2,602)
Headache (2,171)
Overdose (2,082)
Pain (2,080)
Nausea (1,905)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which DIPHENHYDRAMINE Alternatives Have Lower Serotonin syndrome Risk?
DIPHENHYDRAMINE vs DIPHENHYDRAMINE UNKNOWN PRODUCT
DIPHENHYDRAMINE vs DIPHENHYDRAMINE\IBUPROFEN
DIPHENHYDRAMINE vs DIPHENHYDRAMINE\NAPROXEN
DIPHENHYDRAMINE vs DIPHENOXYLATE
DIPHENHYDRAMINE vs DIPHTHERIA AND TETANUS TOXOIDS AND ACELLULAR PERTUSSIS ADSORBED AND INACTIVATED POLIOVIRUS VACCINE