Does DORNASE ALFA Cause Pneumothorax? 39 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 39 reports of Pneumothorax have been filed in association with DORNASE ALFA (Pulmozyme). This represents 0.7% of all adverse event reports for DORNASE ALFA.
39
Reports of Pneumothorax with DORNASE ALFA
0.7%
of all DORNASE ALFA reports
1
Deaths
35
Hospitalizations
How Dangerous Is Pneumothorax From DORNASE ALFA?
Of the 39 reports, 1 (2.6%) resulted in death, 35 (89.7%) required hospitalization, and 1 (2.6%) were considered life-threatening.
Is Pneumothorax Listed in the Official Label?
Yes, Pneumothorax is listed as a known adverse reaction in the official FDA drug label for DORNASE ALFA.
What Other Side Effects Does DORNASE ALFA Cause?
No adverse event (889)
Cystic fibrosis (565)
Off label use (522)
Hospitalisation (512)
Pneumonia (377)
Condition aggravated (304)
Dyspnoea (246)
Infective pulmonary exacerbation of cystic fibrosis (245)
Product storage error (242)
Death (225)
What Other Drugs Cause Pneumothorax?
ADALIMUMAB (530)
METHOTREXATE (380)
NINTEDANIB (310)
BEVACIZUMAB (293)
PREDNISONE (283)
ALBUTEROL (278)
PACLITAXEL (267)
PEMBROLIZUMAB (258)
NIVOLUMAB (254)
CARBOPLATIN (234)
Which DORNASE ALFA Alternatives Have Lower Pneumothorax Risk?
DORNASE ALFA vs DORZOLAMIDE
DORNASE ALFA vs DORZOLAMIDE\TIMOLOL
DORNASE ALFA vs DOSTARLIMAB
DORNASE ALFA vs DOSTARLIMAB-GXLY
DORNASE ALFA vs DOTATATE GALLIUM GA-68