Does METHOTREXATE Cause Pneumothorax? 380 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 380 reports of Pneumothorax have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
380
Reports of Pneumothorax with METHOTREXATE
0.2%
of all METHOTREXATE reports
55
Deaths
250
Hospitalizations
How Dangerous Is Pneumothorax From METHOTREXATE?
Of the 380 reports, 55 (14.5%) resulted in death, 250 (65.8%) required hospitalization, and 64 (16.8%) were considered life-threatening.
Is Pneumothorax Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 380 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Pneumothorax?
ADALIMUMAB (530)
NINTEDANIB (310)
BEVACIZUMAB (293)
PREDNISONE (283)
ALBUTEROL (278)
PACLITAXEL (267)
PEMBROLIZUMAB (258)
NIVOLUMAB (254)
CARBOPLATIN (234)
LENVATINIB (230)
Which METHOTREXATE Alternatives Have Lower Pneumothorax Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA