ESTRADIOL for Hormone replacement therapy: Side Effects & Safety Data

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There are 3,179 adverse event reports in the FDA FAERS database where ESTRADIOL was used for Hormone replacement therapy.

Most Reported Side Effects for ESTRADIOL

Side Effect	Reports	%	Deaths	Hosp.
Product adhesion issue	4,774	15.3%	0	20
Drug ineffective	4,010	12.9%	12	60
Off label use	3,238	10.4%	44	267
Hot flush	2,264	7.3%	0	19
Wrong technique in product usage process	1,871	6.0%	1	19
Product quality issue	1,671	5.4%	0	19
Headache	1,504	4.8%	5	131
No adverse event	1,493	4.8%	0	0
Application site pruritus	1,181	3.8%	0	0
Application site erythema	1,117	3.6%	0	4
Application site rash	894	2.9%	0	2
Nausea	840	2.7%	9	111
Insomnia	812	2.6%	9	47
Rash	778	2.5%	5	63
Vaginal haemorrhage	777	2.5%	0	48