Does GIVOSIRAN Cause Constipation? 8 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 8 reports of Constipation have been filed in association with GIVOSIRAN (GIVLAARI). This represents 0.7% of all adverse event reports for GIVOSIRAN.
8
Reports of Constipation with GIVOSIRAN
0.7%
of all GIVOSIRAN reports
0
Deaths
5
Hospitalizations
How Dangerous Is Constipation From GIVOSIRAN?
Of the 8 reports, 5 (62.5%) required hospitalization, and 1 (12.5%) were considered life-threatening.
Is Constipation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for GIVOSIRAN. However, 8 reports have been filed with the FAERS database.
What Other Side Effects Does GIVOSIRAN Cause?
Porphyria acute (381)
Hospitalisation (141)
Nausea (91)
Product dose omission issue (85)
Fatigue (84)
Therapy interrupted (83)
Pain (74)
Intentional dose omission (63)
Abdominal pain (62)
Vomiting (58)
What Other Drugs Cause Constipation?
LENALIDOMIDE (9,635)
NIRAPARIB (4,128)
ADALIMUMAB (4,063)
SEMAGLUTIDE (4,036)
TIRZEPATIDE (3,417)
ERENUMAB-AOOE (3,104)
MORPHINE (2,979)
OXYCODONE (2,747)
PALBOCICLIB (2,705)
POMALIDOMIDE (2,374)
Which GIVOSIRAN Alternatives Have Lower Constipation Risk?
GIVOSIRAN vs GLASDEGIB
GIVOSIRAN vs GLATIRAMER
GIVOSIRAN vs GLECAPREVIR\PIBRENTASVIR
GIVOSIRAN vs GLEEVEC
GIVOSIRAN vs GLICLAZIDE