GLIVEC for Off label use: Side Effects & Safety Data
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There are 6 adverse event reports in the FDA FAERS database where GLIVEC was used for Off label use.
Most Reported Side Effects for GLIVEC
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Death | 628 | 63.1% | 628 | 14 |
| Malignant neoplasm progression | 60 | 6.0% | 53 | 12 |
| Gastrointestinal stromal tumour | 40 | 4.0% | 30 | 12 |
| Chronic myeloid leukaemia | 38 | 3.8% | 34 | 6 |
| Anaemia | 30 | 3.0% | 18 | 13 |
| Second primary malignancy | 27 | 2.7% | 5 | 12 |
| Pyrexia | 21 | 2.1% | 16 | 9 |
| Blast crisis in myelogenous leukaemia | 20 | 2.0% | 20 | 3 |
| Dyspnoea | 19 | 1.9% | 14 | 9 |
| Malaise | 16 | 1.6% | 7 | 6 |
| Thrombocytopenia | 16 | 1.6% | 10 | 5 |
| Vomiting | 16 | 1.6% | 9 | 11 |
| Diarrhoea | 15 | 1.5% | 6 | 8 |
| General physical health deterioration | 15 | 1.5% | 13 | 8 |
| Nausea | 15 | 1.5% | 10 | 8 |
Other Indications for GLIVEC
Chronic myeloid leukaemia (636)
Gastrointestinal stromal tumour (231)
Acute lymphocytic leukaemia (61)
Gastrointestinal neoplasm (61)
Chromosome analysis abnormal (14)
Acute myeloid leukaemia (10)
Other Drugs Used for Off label use
LENALIDOMIDE (5,767)
ECULIZUMAB (3,550)
CERTOLIZUMAB PEGOL (2,256)
ABOBOTULINUMTOXINA (2,170)
LEVETIRACETAM (2,161)
APREMILAST (1,995)
PROPRANOLOL (1,576)
CETIRIZINE (1,416)
HUMAN IMMUNOGLOBULIN G (1,129)
THALIDOMIDE (1,033)