Does METHADONE Cause Serotonin syndrome? 133 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 133 reports of Serotonin syndrome have been filed in association with METHADONE (METHADONE HYDROCHLORIDE). This represents 0.5% of all adverse event reports for METHADONE.
133
Reports of Serotonin syndrome with METHADONE
0.5%
of all METHADONE reports
17
Deaths
72
Hospitalizations
How Dangerous Is Serotonin syndrome From METHADONE?
Of the 133 reports, 17 (12.8%) resulted in death, 72 (54.1%) required hospitalization, and 13 (9.8%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
Yes, Serotonin syndrome is listed as a known adverse reaction in the official FDA drug label for METHADONE.
What Other Side Effects Does METHADONE Cause?
Drug dependence (5,739)
Toxicity to various agents (4,586)
Drug abuse (4,480)
Overdose (3,472)
Pain (2,754)
Death (2,716)
Emotional distress (2,388)
Drug withdrawal syndrome (2,127)
Foetal exposure during pregnancy (1,759)
Drug withdrawal syndrome neonatal (1,458)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which METHADONE Alternatives Have Lower Serotonin syndrome Risk?
METHADONE vs METHAMPHETAMINE
METHADONE vs METHENAMINE HIPPURATE
METHADONE vs METHIMAZOLE
METHADONE vs METHOCARBAMOL
METHADONE vs METHOHEXITAL