Does PACLITAXEL Cause Cholestasis? 208 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 208 reports of Cholestasis have been filed in association with PACLITAXEL (PACLITAXEL PACLITAXEL). This represents 0.3% of all adverse event reports for PACLITAXEL.
208
Reports of Cholestasis with PACLITAXEL
0.3%
of all PACLITAXEL reports
22
Deaths
115
Hospitalizations
How Dangerous Is Cholestasis From PACLITAXEL?
Of the 208 reports, 22 (10.6%) resulted in death, 115 (55.3%) required hospitalization, and 4 (1.9%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PACLITAXEL. However, 208 reports have been filed with the FAERS database.
What Other Side Effects Does PACLITAXEL Cause?
Neutropenia (4,553)
Nausea (4,521)
Dyspnoea (4,519)
Diarrhoea (4,289)
Off label use (4,075)
Anaemia (3,949)
Neuropathy peripheral (3,508)
Malignant neoplasm progression (3,484)
Fatigue (3,418)
Death (3,143)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which PACLITAXEL Alternatives Have Lower Cholestasis Risk?
PACLITAXEL vs PACRITINIB
PACLITAXEL vs PALBOCICLIB
PACLITAXEL vs PALIPERIDONE
PACLITAXEL vs PALIVIZUMAB
PACLITAXEL vs PALONOSETRON