Cholestasis: Which Medications Cause It? (13,105 Reports Across 797 Drugs)
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Cholestasis has been reported as an adverse event with 797 different drugs in the FDA's FAERS database, with 13,105 total reports. 1,045 of these reports resulted in death.The drugs most commonly associated with Cholestasis are ACETAMINOPHEN, ATORVASTATIN, and PANTOPRAZOLE.
13,105
Total Reports
797
Drugs Involved
1,045
Deaths
7,509
Hospitalizations
60.2 yrs
Average Patient Age
53.5% / 46.5%
Female / Male
Which Drugs Cause Cholestasis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 1,269 | 0.9% | 57 | 737 | 73 |
| ATORVASTATIN | 898 | 1.1% | 48 | 558 | 33 |
| PANTOPRAZOLE | 535 | 0.7% | 35 | 312 | 19 |
| METHOTREXATE | 507 | 0.2% | 34 | 268 | 46 |
| AMOXICILLIN\CLAVULANATE | 480 | 3.1% | 21 | 341 | 18 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 462 | 1.2% | 21 | 323 | 20 |
| ENOXAPARIN | 404 | 1.6% | 7 | 215 | 6 |
| PIPERACILLIN\TAZOBACTAM | 394 | 2.1% | 17 | 254 | 36 |
| ESOMEPRAZOLE | 363 | 0.5% | 23 | 243 | 6 |
| NIVOLUMAB | 342 | 0.4% | 41 | 202 | 10 |
| AMOXICILLIN | 326 | 1.1% | 20 | 198 | 6 |
| LANSOPRAZOLE | 322 | 0.5% | 13 | 205 | 7 |
| LEVOFLOXACIN | 320 | 0.8% | 19 | 210 | 9 |
| TRAMADOL | 305 | 0.4% | 11 | 188 | 22 |
| CARBOPLATIN | 295 | 0.4% | 16 | 140 | 14 |
| TACROLIMUS | 291 | 0.3% | 74 | 197 | 29 |
| FUROSEMIDE | 288 | 0.6% | 36 | 191 | 16 |
| PEMBROLIZUMAB | 273 | 0.3% | 15 | 141 | 8 |
| VINCRISTINE | 273 | 0.4% | 12 | 112 | 24 |
| CEFTRIAXONE | 261 | 1.3% | 29 | 165 | 8 |