PEMBROLIZUMAB for Prophylaxis: Side Effects & Safety Data
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There are 12 adverse event reports in the FDA FAERS database where PEMBROLIZUMAB was used for Prophylaxis.
Most Reported Side Effects for PEMBROLIZUMAB
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Malignant neoplasm progression | 10,111 | 12.1% | 5,124 | 3,426 |
| Death | 4,744 | 5.7% | 4,737 | 893 |
| Diarrhoea | 4,251 | 5.1% | 556 | 2,141 |
| Fatigue | 3,833 | 4.6% | 365 | 1,246 |
| Off label use | 3,416 | 4.1% | 747 | 1,045 |
| Product use in unapproved indication | 3,191 | 3.8% | 514 | 909 |
| Pyrexia | 3,155 | 3.8% | 444 | 2,194 |
| Rash | 2,900 | 3.5% | 289 | 1,047 |
| Nausea | 2,670 | 3.2% | 335 | 1,237 |
| Decreased appetite | 2,486 | 3.0% | 371 | 1,235 |
| Hypothyroidism | 2,326 | 2.8% | 242 | 935 |
| Product use issue | 2,323 | 2.8% | 417 | 610 |
| Hypertension | 2,245 | 2.7% | 276 | 1,118 |
| Asthenia | 2,131 | 2.5% | 300 | 1,058 |
| Interstitial lung disease | 2,113 | 2.5% | 869 | 1,276 |
Other Indications for PEMBROLIZUMAB
Non-small cell lung cancer (6,893)
Triple negative breast cancer (5,148)
Endometrial cancer (4,343)
Lung adenocarcinoma (3,954)
Lung neoplasm malignant (3,575)
Malignant melanoma (3,261)
Renal cell carcinoma (3,027)
Metastatic malignant melanoma (2,742)
Uterine cancer (2,223)
Product used for unknown indication (2,091)
Other Drugs Used for Prophylaxis
PEGFILGRASTIM (7,424)
HUMAN C1-ESTERASE INHIBITOR (5,950)
DENOSUMAB (4,541)
SULFAMETHOXAZOLE\TRIMETHOPRIM (3,197)
ASPIRIN (2,083)
VALACYCLOVIR (1,574)
PANTOPRAZOLE (1,502)
VARICELLA-ZOSTER VIRUS STRAIN OKA/MERCK LIVE ANTIGEN (1,444)
CLOPIDOGREL BISULFATE (1,296)
ENOXAPARIN (1,278)