Does PEMBROLIZUMAB Cause Hypophysitis? 411 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 411 reports of Hypophysitis have been filed in association with PEMBROLIZUMAB (KEYTRUDA). This represents 0.5% of all adverse event reports for PEMBROLIZUMAB.
411
Reports of Hypophysitis with PEMBROLIZUMAB
0.5%
of all PEMBROLIZUMAB reports
32
Deaths
233
Hospitalizations
How Dangerous Is Hypophysitis From PEMBROLIZUMAB?
Of the 411 reports, 32 (7.8%) resulted in death, 233 (56.7%) required hospitalization, and 50 (12.2%) were considered life-threatening.
Is Hypophysitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMBROLIZUMAB. However, 411 reports have been filed with the FAERS database.
What Other Side Effects Does PEMBROLIZUMAB Cause?
Malignant neoplasm progression (10,111)
Death (4,744)
Diarrhoea (4,251)
Fatigue (3,833)
Off label use (3,416)
Product use in unapproved indication (3,191)
Pyrexia (3,155)
Rash (2,900)
Nausea (2,670)
Decreased appetite (2,486)
What Other Drugs Cause Hypophysitis?
IPILIMUMAB (981)
NIVOLUMAB (755)
CARBOPLATIN (144)
ATEZOLIZUMAB (125)
PACLITAXEL (110)
BEVACIZUMAB (61)
DURVALUMAB (60)
PEMETREXED (51)
CYCLOPHOSPHAMIDE (38)
LENVATINIB (32)
Which PEMBROLIZUMAB Alternatives Have Lower Hypophysitis Risk?
PEMBROLIZUMAB vs PEMETREXED
PEMBROLIZUMAB vs PEMIGATINIB
PEMBROLIZUMAB vs PENICILLAMINE
PEMBROLIZUMAB vs PENICILLIN
PEMBROLIZUMAB vs PENICILLIN G