Hypophysitis: Which Medications Cause It? (1,790 Reports Across 78 Drugs)
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Hypophysitis has been reported as an adverse event with 78 different drugs in the FDA's FAERS database, with 1,790 total reports. 138 of these reports resulted in death.The drugs most commonly associated with Hypophysitis are IPILIMUMAB, NIVOLUMAB, and PEMBROLIZUMAB.
1,790
Total Reports
78
Drugs Involved
138
Deaths
972
Hospitalizations
61.0 yrs
Average Patient Age
43.2% / 56.8%
Female / Male
Which Drugs Cause Hypophysitis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| IPILIMUMAB | 981 | 2.7% | 61 | 515 | 91 |
| NIVOLUMAB | 755 | 0.9% | 58 | 485 | 85 |
| PEMBROLIZUMAB | 411 | 0.5% | 32 | 233 | 50 |
| CARBOPLATIN | 144 | 0.2% | 22 | 96 | 30 |
| ATEZOLIZUMAB | 125 | 0.4% | 20 | 49 | 3 |
| PACLITAXEL | 110 | 0.1% | 8 | 81 | 21 |
| BEVACIZUMAB | 61 | 0.1% | 15 | 32 | 3 |
| DURVALUMAB | 60 | 0.4% | 16 | 17 | 8 |
| PEMETREXED | 51 | 0.2% | 15 | 36 | 10 |
| CYCLOPHOSPHAMIDE | 38 | 0.0% | 0 | 28 | 20 |
| LENVATINIB | 32 | 0.1% | 3 | 21 | 1 |
| EPIRUBICIN | 30 | 0.2% | 0 | 24 | 21 |
| DABRAFENIB | 27 | 0.1% | 3 | 12 | 2 |
| CISPLATIN | 18 | 0.0% | 3 | 9 | 2 |
| TRAMETINIB | 18 | 0.3% | 1 | 5 | 0 |
| TRASTUZUMAB | 17 | 0.0% | 1 | 6 | 0 |
| VEMURAFENIB | 17 | 0.2% | 0 | 4 | 0 |
| AVELUMAB | 15 | 0.4% | 4 | 3 | 0 |
| TREMELIMUMAB | 15 | 0.6% | 6 | 6 | 0 |
| ETOPOSIDE | 14 | 0.0% | 0 | 4 | 1 |