Does PEMETREXED Cause Extremity necrosis? 45 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 45 reports of Extremity necrosis have been filed in association with PEMETREXED (Pemetrexed). This represents 0.2% of all adverse event reports for PEMETREXED.
45
Reports of Extremity necrosis with PEMETREXED
0.2%
of all PEMETREXED reports
1
Deaths
34
Hospitalizations
How Dangerous Is Extremity necrosis From PEMETREXED?
Of the 45 reports, 1 (2.2%) resulted in death, 34 (75.6%) required hospitalization, and 2 (4.4%) were considered life-threatening.
Is Extremity necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMETREXED. However, 45 reports have been filed with the FAERS database.
What Other Side Effects Does PEMETREXED Cause?
Malignant neoplasm progression (2,149)
Off label use (1,663)
Anaemia (1,430)
Pancytopenia (1,236)
Neutropenia (1,200)
Nausea (1,195)
Diarrhoea (1,165)
Acute kidney injury (1,105)
Thrombocytopenia (1,059)
Disease progression (969)
What Other Drugs Cause Extremity necrosis?
CANAGLIFLOZIN (95)
CALCIUM\DEXTROSE\MAGNESIUM\SODIUM\SODIUM (84)
CARBOPLATIN (46)
ADALIMUMAB (42)
GEMCITABINE (40)
METHYLPREDNISOLONE (40)
EPINEPHRINE (39)
PEMBROLIZUMAB (37)
NOREPINEPHRINE (34)
DAPAGLIFLOZIN (29)
Which PEMETREXED Alternatives Have Lower Extremity necrosis Risk?
PEMETREXED vs PEMIGATINIB
PEMETREXED vs PENICILLAMINE
PEMETREXED vs PENICILLIN
PEMETREXED vs PENICILLIN G
PEMETREXED vs PENICILLIN G BENZATHINE