Extremity necrosis: Which Medications Cause It? (1,232 Reports Across 131 Drugs)
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Extremity necrosis has been reported as an adverse event with 131 different drugs in the FDA's FAERS database, with 1,232 total reports. 160 of these reports resulted in death.The drugs most commonly associated with Extremity necrosis are CANAGLIFLOZIN, CALCIUM\DEXTROSE\MAGNESIUM\SODIUM\SODIUM, and CARBOPLATIN.
1,232
Total Reports
131
Drugs Involved
160
Deaths
810
Hospitalizations
59.6 yrs
Average Patient Age
45.2% / 54.8%
Female / Male
Which Drugs Cause Extremity necrosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CANAGLIFLOZIN | 95 | 0.4% | 0 | 76 | 0 |
| CALCIUM\DEXTROSE\MAGNESIUM\SODIUM\SODIUM | 84 | 0.1% | 45 | 76 | 0 |
| CARBOPLATIN | 46 | 0.1% | 0 | 33 | 2 |
| PEMETREXED | 45 | 0.2% | 1 | 34 | 2 |
| ADALIMUMAB | 42 | 0.0% | 4 | 30 | 0 |
| GEMCITABINE | 40 | 0.1% | 1 | 27 | 1 |
| METHYLPREDNISOLONE | 40 | 0.1% | 4 | 37 | 18 |
| EPINEPHRINE | 39 | 0.3% | 0 | 18 | 2 |
| PEMBROLIZUMAB | 37 | 0.0% | 2 | 29 | 4 |
| NOREPINEPHRINE | 34 | 0.7% | 3 | 25 | 4 |
| DAPAGLIFLOZIN | 29 | 0.1% | 1 | 15 | 1 |
| BISOPROLOL | 28 | 0.1% | 0 | 22 | 0 |
| CISPLATIN | 26 | 0.1% | 3 | 15 | 0 |
| ASPIRIN | 25 | 0.0% | 1 | 21 | 12 |
| CIPROFLOXACIN | 25 | 0.1% | 1 | 23 | 13 |
| EMPAGLIFLOZIN | 24 | 0.1% | 1 | 11 | 4 |
| RITUXIMAB | 24 | 0.0% | 4 | 9 | 1 |
| BOSENTAN | 23 | 0.1% | 2 | 21 | 2 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 23 | 0.1% | 6 | 17 | 17 |
| RIVAROXABAN | 22 | 0.0% | 1 | 15 | 3 |