Does PEMETREXED Cause Immune-mediated hepatitis? 86 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 86 reports of Immune-mediated hepatitis have been filed in association with PEMETREXED (Pemetrexed). This represents 0.4% of all adverse event reports for PEMETREXED.
86
Reports of Immune-mediated hepatitis with PEMETREXED
0.4%
of all PEMETREXED reports
7
Deaths
52
Hospitalizations
How Dangerous Is Immune-mediated hepatitis From PEMETREXED?
Of the 86 reports, 7 (8.1%) resulted in death, 52 (60.5%) required hospitalization, and 18 (20.9%) were considered life-threatening.
Is Immune-mediated hepatitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMETREXED. However, 86 reports have been filed with the FAERS database.
What Other Side Effects Does PEMETREXED Cause?
Malignant neoplasm progression (2,149)
Off label use (1,663)
Anaemia (1,430)
Pancytopenia (1,236)
Neutropenia (1,200)
Nausea (1,195)
Diarrhoea (1,165)
Acute kidney injury (1,105)
Thrombocytopenia (1,059)
Disease progression (969)
What Other Drugs Cause Immune-mediated hepatitis?
NIVOLUMAB (640)
PEMBROLIZUMAB (549)
IPILIMUMAB (443)
CARBOPLATIN (213)
PACLITAXEL (167)
ATEZOLIZUMAB (142)
BEVACIZUMAB (108)
DURVALUMAB (90)
LENVATINIB (86)
TREMELIMUMAB (51)
Which PEMETREXED Alternatives Have Lower Immune-mediated hepatitis Risk?
PEMETREXED vs PEMIGATINIB
PEMETREXED vs PENICILLAMINE
PEMETREXED vs PENICILLIN
PEMETREXED vs PENICILLIN G
PEMETREXED vs PENICILLIN G BENZATHINE