Does PHENYTOIN Cause Serotonin syndrome? 55 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 55 reports of Serotonin syndrome have been filed in association with PHENYTOIN (PHENYTOIN SODIUM). This represents 0.4% of all adverse event reports for PHENYTOIN.
55
Reports of Serotonin syndrome with PHENYTOIN
0.4%
of all PHENYTOIN reports
17
Deaths
35
Hospitalizations
How Dangerous Is Serotonin syndrome From PHENYTOIN?
Of the 55 reports, 17 (30.9%) resulted in death, 35 (63.6%) required hospitalization, and 6 (10.9%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PHENYTOIN. However, 55 reports have been filed with the FAERS database.
What Other Side Effects Does PHENYTOIN Cause?
Drug ineffective (2,753)
Seizure (1,907)
Toxicity to various agents (1,248)
Drug hypersensitivity (898)
Off label use (852)
Drug interaction (772)
Drug reaction with eosinophilia and systemic symptoms (673)
Status epilepticus (544)
Fall (436)
Rash (414)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which PHENYTOIN Alternatives Have Lower Serotonin syndrome Risk?
PHENYTOIN vs PHLEUM PRATENSE POLLEN
PHENYTOIN vs PHLOROGLUCINOL
PHENYTOIN vs PHLOROGLUCINOL\1,3,5-TRIMETHOXYBENZENE
PHENYTOIN vs PHOLCODINE
PHENYTOIN vs PHOSPHORUS