Does PONATINIB Cause Cholestasis? 28 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 28 reports of Cholestasis have been filed in association with PONATINIB (Iclusig). This represents 0.3% of all adverse event reports for PONATINIB.
28
Reports of Cholestasis with PONATINIB
0.3%
of all PONATINIB reports
4
Deaths
22
Hospitalizations
How Dangerous Is Cholestasis From PONATINIB?
Of the 28 reports, 4 (14.3%) resulted in death, 22 (78.6%) required hospitalization, and 5 (17.9%) were considered life-threatening.
Is Cholestasis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PONATINIB. However, 28 reports have been filed with the FAERS database.
What Other Side Effects Does PONATINIB Cause?
Death (1,735)
Off label use (1,071)
Product dose omission issue (817)
Fatigue (687)
Rash (639)
Headache (553)
Pyrexia (542)
Nausea (466)
Hospitalisation (459)
Constipation (435)
What Other Drugs Cause Cholestasis?
ACETAMINOPHEN (1,269)
ATORVASTATIN (898)
PANTOPRAZOLE (535)
METHOTREXATE (507)
AMOXICILLIN\CLAVULANATE (480)
SULFAMETHOXAZOLE\TRIMETHOPRIM (462)
ENOXAPARIN (404)
PIPERACILLIN\TAZOBACTAM (394)
ESOMEPRAZOLE (363)
NIVOLUMAB (342)
Which PONATINIB Alternatives Have Lower Cholestasis Risk?
PONATINIB vs PONATINIB\PONATINIB
PONATINIB vs PONESIMOD
PONATINIB vs PORACTANT ALFA
PONATINIB vs PORFIMER
PONATINIB vs POSACONAZOLE