Does RASBURICASE Cause Neutropenia? 19 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 19 reports of Neutropenia have been filed in association with RASBURICASE (Elitek). This represents 2.2% of all adverse event reports for RASBURICASE.
19
Reports of Neutropenia with RASBURICASE
2.2%
of all RASBURICASE reports
9
Deaths
12
Hospitalizations
How Dangerous Is Neutropenia From RASBURICASE?
Of the 19 reports, 9 (47.4%) resulted in death, 12 (63.2%) required hospitalization, and 3 (15.8%) were considered life-threatening.
Is Neutropenia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for RASBURICASE. However, 19 reports have been filed with the FAERS database.
What Other Side Effects Does RASBURICASE Cause?
Tumour lysis syndrome (116)
Methaemoglobinaemia (92)
Off label use (90)
Product use in unapproved indication (76)
Bacterial infection (75)
Fungal infection (73)
Cellulitis (72)
Clostridium difficile colitis (72)
Lymphoid tissue hypoplasia (72)
Lymphopenia (72)
What Other Drugs Cause Neutropenia?
CLOZAPINE (18,981)
CYCLOPHOSPHAMIDE (7,352)
LENALIDOMIDE (6,909)
RITUXIMAB (6,607)
PALBOCICLIB (6,423)
DEXAMETHASONE (6,050)
DOXORUBICIN (5,891)
CARBOPLATIN (5,314)
VINCRISTINE (4,982)
PACLITAXEL (4,553)
Which RASBURICASE Alternatives Have Lower Neutropenia Risk?
RASBURICASE vs RAVULIZUMAB
RASBURICASE vs RAVULIZUMAB-CWVZ
RASBURICASE vs REBAMIPIDE
RASBURICASE vs REBETOL
RASBURICASE vs REBIF