Does SPIRONOLACTONE Cause Serotonin syndrome? 33 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 33 reports of Serotonin syndrome have been filed in association with SPIRONOLACTONE (spironolactone). This represents 0.2% of all adverse event reports for SPIRONOLACTONE.
33
Reports of Serotonin syndrome with SPIRONOLACTONE
0.2%
of all SPIRONOLACTONE reports
17
Deaths
21
Hospitalizations
How Dangerous Is Serotonin syndrome From SPIRONOLACTONE?
Of the 33 reports, 17 (51.5%) resulted in death, 21 (63.6%) required hospitalization, and 12 (36.4%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for SPIRONOLACTONE. However, 33 reports have been filed with the FAERS database.
What Other Side Effects Does SPIRONOLACTONE Cause?
Acute kidney injury (3,273)
Hyperkalaemia (2,518)
Hypotension (1,583)
Dyspnoea (1,468)
Drug ineffective (1,379)
Hyponatraemia (1,166)
Dizziness (991)
Fatigue (990)
Fall (947)
Off label use (899)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which SPIRONOLACTONE Alternatives Have Lower Serotonin syndrome Risk?
SPIRONOLACTONE vs SPRYCEL
SPIRONOLACTONE vs STALEVO
SPIRONOLACTONE vs STANNOUS FLUORIDE
SPIRONOLACTONE vs STANOZOLOL
SPIRONOLACTONE vs STAVUDINE