Does TOPIRAMATE Cause Serotonin syndrome? 158 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 158 reports of Serotonin syndrome have been filed in association with TOPIRAMATE (Topiramate). This represents 0.6% of all adverse event reports for TOPIRAMATE.
158
Reports of Serotonin syndrome with TOPIRAMATE
0.6%
of all TOPIRAMATE reports
8
Deaths
86
Hospitalizations
How Dangerous Is Serotonin syndrome From TOPIRAMATE?
Of the 158 reports, 8 (5.1%) resulted in death, 86 (54.4%) required hospitalization, and 19 (12.0%) were considered life-threatening.
Is Serotonin syndrome Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TOPIRAMATE. However, 158 reports have been filed with the FAERS database.
What Other Side Effects Does TOPIRAMATE Cause?
Drug ineffective (5,553)
Off label use (4,248)
Product use in unapproved indication (2,173)
Headache (1,997)
Drug intolerance (1,820)
Migraine (1,796)
Nausea (1,691)
Seizure (1,535)
Paraesthesia (1,506)
Dizziness (1,466)
What Other Drugs Cause Serotonin syndrome?
VENLAFAXINE (1,632)
SERTRALINE (1,563)
FLUOXETINE (1,457)
DULOXETINE (1,352)
TRAMADOL (1,229)
BUPROPION (1,058)
ESCITALOPRAM OXALATE (1,051)
QUETIAPINE (947)
TRAZODONE (831)
FENTANYL (778)
Which TOPIRAMATE Alternatives Have Lower Serotonin syndrome Risk?
TOPIRAMATE vs TOPOTECAN
TOPIRAMATE vs TOPOTECAN\TOPOTECAN
TOPIRAMATE vs TOPROL
TOPIRAMATE vs TOREMIFENE
TOPIRAMATE vs TORIPALIMAB