Does TOPIRAMATE Cause Synovitis? 633 Reports in FDA Database

Q: Does TOPIRAMATE cause Synovitis?

633 reports of Synovitis have been filed with the FDA for TOPIRAMATE, representing 2.2% of all TOPIRAMATE adverse event reports.

Q: How dangerous is Synovitis from TOPIRAMATE?

Of 633 reports, 618 (97.6%) resulted in death and 561 required hospitalization.

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According to the FDA Adverse Event Reporting System (FAERS), 633 reports of Synovitis have been filed in association with TOPIRAMATE (Topiramate). This represents 2.2% of all adverse event reports for TOPIRAMATE.

633

Reports of Synovitis with TOPIRAMATE

2.2%

of all TOPIRAMATE reports

618

Deaths

561

Hospitalizations

How Dangerous Is Synovitis From TOPIRAMATE?

Of the 633 reports, 618 (97.6%) resulted in death, 561 (88.6%) required hospitalization, and 575 (90.8%) were considered life-threatening.

Is Synovitis Listed in the Official Label?

This adverse event is not currently listed in the official FDA drug label for TOPIRAMATE. However, 633 reports have been filed with the FAERS database.

What Other Side Effects Does TOPIRAMATE Cause?

Drug ineffective (5,553) Off label use (4,248) Product use in unapproved indication (2,173) Headache (1,997) Drug intolerance (1,820) Migraine (1,796) Nausea (1,691) Seizure (1,535) Paraesthesia (1,506) Dizziness (1,466)

What Other Drugs Cause Synovitis?

METHOTREXATE (11,451) ADALIMUMAB (9,965) ABATACEPT (9,783) ETANERCEPT (9,599) TOCILIZUMAB (9,428) HYDROXYCHLOROQUINE (9,123) LEFLUNOMIDE (8,889) RITUXIMAB (7,956) INFLIXIMAB (7,856) SULFASALAZINE (7,566)

Which TOPIRAMATE Alternatives Have Lower Synovitis Risk?

TOPIRAMATE vs TOPOTECAN TOPIRAMATE vs TOPOTECAN\TOPOTECAN TOPIRAMATE vs TOPROL TOPIRAMATE vs TOREMIFENE TOPIRAMATE vs TORIPALIMAB

TOPIRAMATE Full Profile All Synovitis Reports All Drugs Causing Synovitis TOPIRAMATE Demographics