Does METHOTREXATE Cause Synovitis? 11,451 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 11,451 reports of Synovitis have been filed in association with METHOTREXATE (Methotrexate). This represents 4.5% of all adverse event reports for METHOTREXATE.
11,451
Reports of Synovitis with METHOTREXATE
4.5%
of all METHOTREXATE reports
1,943
Deaths
3,783
Hospitalizations
How Dangerous Is Synovitis From METHOTREXATE?
Of the 11,451 reports, 1,943 (17.0%) resulted in death, 3,783 (33.0%) required hospitalization, and 2,328 (20.3%) were considered life-threatening.
Is Synovitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 11,451 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Synovitis?
ADALIMUMAB (9,965)
ABATACEPT (9,783)
ETANERCEPT (9,599)
TOCILIZUMAB (9,428)
HYDROXYCHLOROQUINE (9,123)
LEFLUNOMIDE (8,889)
RITUXIMAB (7,956)
INFLIXIMAB (7,856)
SULFASALAZINE (7,566)
TOFACITINIB (7,272)
Which METHOTREXATE Alternatives Have Lower Synovitis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA