XGEVA for Prophylaxis: Side Effects & Safety Data
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There are 385 adverse event reports in the FDA FAERS database where XGEVA was used for Prophylaxis.
Most Reported Side Effects for XGEVA
| Side Effect | Reports | % | Deaths | Hosp. |
|---|---|---|---|---|
| Death | 309 | 29.7% | 309 | 24 |
| Osteonecrosis of jaw | 159 | 15.3% | 5 | 14 |
| Investigation | 115 | 11.0% | 11 | 115 |
| Hospitalisation | 77 | 7.4% | 4 | 77 |
| Hypocalcaemia | 48 | 4.6% | 7 | 34 |
| Metastases to bone | 30 | 2.9% | 3 | 2 |
| Pain | 28 | 2.7% | 2 | 9 |
| Pain in extremity | 17 | 1.6% | 1 | 5 |
| Dyspnoea | 16 | 1.5% | 5 | 9 |
| Disease progression | 15 | 1.4% | 6 | 4 |
| Terminal state | 14 | 1.3% | 0 | 2 |
| Back pain | 13 | 1.3% | 0 | 2 |
| Fatigue | 13 | 1.3% | 1 | 4 |
| Hypoaesthesia | 13 | 1.3% | 5 | 6 |
| Malaise | 13 | 1.3% | 2 | 6 |
Other Indications for XGEVA
Metastases to bone (412)
Product used for unknown indication (349)
Prostate cancer (32)
Prostate cancer metastatic (25)
Breast cancer metastatic (24)
Breast cancer (23)
Bone disorder (7)
Osteoporosis (6)
Neoplasm malignant (5)
Other Drugs Used for Prophylaxis
PEGFILGRASTIM (7,424)
HUMAN C1-ESTERASE INHIBITOR (5,950)
DENOSUMAB (4,541)
SULFAMETHOXAZOLE\TRIMETHOPRIM (3,197)
ASPIRIN (2,083)
VALACYCLOVIR (1,574)
PANTOPRAZOLE (1,502)
VARICELLA-ZOSTER VIRUS STRAIN OKA/MERCK LIVE ANTIGEN (1,444)
CLOPIDOGREL BISULFATE (1,296)
ENOXAPARIN (1,278)