Cytochrome P450 3A Inducers [MoA]: Side Effects & Safety Data for 17 Drugs
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Cytochrome P450 3A Inducers [MoA] includes 17 drugs with a combined 99,563 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
17
Drugs in Class
99,563
Combined Reports
All Cytochrome P450 3A Inducers [MoA] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| RELUGOLIX | Orgovyx | 20,660 | 958 | 1,699 | 4.6% |
| BOSENTAN | Tracleer | 19,581 | 4,346 | 8,862 | 22.2% |
| PHENYTOIN | PHENYTOIN SODIUM | 14,469 | 1,449 | 5,241 | 10.0% |
| RITONAVIR | Norvir | 11,980 | 1,190 | 2,925 | 9.9% |
| EFAVIRENZ | Efavirenz, Emtricitabine and Tenofovir Disoproxil Fumarate | 7,893 | 962 | 1,528 | 12.2% |
| NEVIRAPINE | Nevirapine | 6,651 | 1,101 | 979 | 16.6% |
| LORLATINIB | Lorbrena | 5,508 | 1,542 | 1,232 | 28.0% |
| ELAGOLIX | Orilissa | 3,582 | 5 | 299 | 0.1% |
| BRIGATINIB | Alunbrig | 3,286 | 729 | 912 | 22.2% |
| ETRAVIRINE | Intelence | 1,969 | 257 | 405 | 13.1% |
| FOSPHENYTOIN | CEREBYX | 1,378 | 166 | 646 | 12.0% |
| PEXIDARTINIB | Turalio | 970 | 17 | 91 | 1.8% |
| MITAPIVAT | PYRUKYND | 627 | 4 | 58 | 0.6% |
| SUZETRIGINE | JOURNAVX | 407 | 1 | 13 | 0.2% |
| VORASIDENIB | VORANIGO | 264 | 6 | 57 | 2.3% |
| TOVORAFENIB | OJEMDA | 201 | 6 | 18 | 3.0% |
| TECOVIRIMAT | TPOXX | 137 | 27 | 43 | 19.7% |
Common Side Effects in Cytochrome P450 3A Inducers [MoA] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Fatigue | 7,997 | 269 |
| Hot flush | 7,378 | 28 |
| Death | 6,338 | 6,322 |
| Drug ineffective | 4,892 | 455 |
| Foetal exposure during pregnancy | 4,467 | 759 |
| Dyspnoea | 3,620 | 625 |
| Diarrhoea | 3,603 | 274 |
| Off label use | 3,478 | 566 |
| Therapy interrupted | 3,475 | 20 |
| Nausea | 3,155 | 171 |