Topoisomerase Inhibitor [EPC]: Side Effects & Safety Data for 4 Drugs
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Topoisomerase Inhibitor [EPC] includes 4 drugs with a combined 88,271 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.
4
Drugs in Class
88,271
Combined Reports
All Topoisomerase Inhibitor [EPC] Drugs Ranked by Reports
| Drug | Brand Name | Reports | Deaths | Hosp. | Death Rate |
|---|---|---|---|---|---|
| ETOPOSIDE | Avopef | 52,603 | 11,780 | 17,699 | 22.4% |
| IRINOTECAN | Irinotecan Hydrochloride | 27,965 | 4,530 | 10,384 | 16.2% |
| MITOXANTRONE | mitoXANTRONE | 4,166 | 995 | 1,556 | 23.9% |
| TOPOTECAN | HYCAMTIN | 3,537 | 773 | 1,213 | 21.9% |
Common Side Effects in Topoisomerase Inhibitor [EPC] Drugs
| Side Effect | Reports | Deaths |
|---|---|---|
| Febrile neutropenia | 20,138 | 2,615 |
| Off label use | 18,583 | 4,109 |
| Neutropenia | 14,556 | 2,248 |
| Disease progression | 13,068 | 3,490 |
| Drug ineffective | 10,956 | 3,323 |
| Diarrhoea | 9,498 | 1,486 |
| Thrombocytopenia | 9,481 | 1,727 |
| Pyrexia | 9,448 | 1,320 |
| Nausea | 8,887 | 888 |
| Anaemia | 8,661 | 1,289 |